Gregory T Went

Title: Gregory T Went: Innovator in Biopolymer Analysis and Pharmacophore Structure Determination

Introduction

Gregory T Went is a prominent inventor based in Madison, CT (US), known for his significant contributions to the fields of biopolymer analysis and pharmacophore structure determination. With a total of 10 patents, his work has advanced the understanding and application of biopolymers in various scientific domains.

Latest Patents

One of his latest patents is an "Apparatus and method for the generation, separation, detection, and recognition of biopolymer fragments." This invention features an integrated instrument designed for high-capacity electrophoretic analysis of biopolymer samples. It includes a specialized high-voltage electrophoretic module that allows for the concurrent separation of 80 or more samples. The system is equipped with a thermal control module that utilizes Peltier heat transfer devices to manage temperature and gradients in the electrophoretic medium. Detection is achieved through a transmission imaging spectrograph, which spatially focuses and spectrally resolves the detection region of all migration lanes. The analysis process incorporates noise filtering and a Monte-Carlo simulated annealing algorithm for improved results.

Another notable patent is the "Consensus configurational bias Monte Carlo method and system for pharmacophore structure determination." This method aims to determine an accurate pharmacophore structure shared by compounds that selectively bind to a target molecule. The process begins with screening a diversity library against the target molecule to identify selectively binding members. The structure of these members is then examined to determine a candidate pharmacophore. The method employs REDOR nuclear magnetic resonance to ascertain interatomic distances, which are used to refine the pharmacophore structure through a highly accurate Monte Carlo method.

Career Highlights

Gregory T Went has made significant strides in his career, particularly through his work at Curagen Corporation. His innovative approaches have not only contributed to scientific knowledge but have also paved the way for advancements in drug development and biopolymer research.

Collaborations

Throughout his career, Gregory has collaborated with notable figures in the field, including Jonathan Marc Rothberg and John W Simpson. These collaborations have further enhanced the impact of his inventions and research.

Conclusion

Gregory T Went's contributions to the fields of biopolymer analysis and pharmacophore structure determination exemplify the importance of innovation in scientific research