Company Filing History:
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1 out of 3 Years Active: 1998-2010
Title: Gregory I Frost: Innovator in Hyaluronidase Research
Introduction
Gregory I Frost is a notable inventor based in San Francisco, CA (US). He has made significant contributions to the field of biochemistry, particularly in the purification and application of human plasma hyaluronidase. With a total of 8 patents to his name, Frost's work has implications for cancer treatment and therapeutic methods.
Latest Patents
Frost's latest patents focus on the discovery of methods for the purification of an acid active hyaluronidase found in human plasma, known as hpHAse. This invention includes both biochemical and immunoaffinity purification methods. The immunoaffinity purification method is based on identifying antibodies that specifically bind to native hpHAse, referred to as anti-native hpHAse antibodies. Additionally, the invention features an assay for the sensitive detection of HAse activity using biotinylated hyaluronic acid (bHA). Through the purification and characterization of hpHAse, Frost discovered that it is encoded by the LuCa-1 gene, located on human chromosome 3p21.3, a region associated with tumor suppression. His inventions also include methods for treating tumor-bearing patients through the administration of hpHAse and/or transformation of cells with hpHAse-encoding DNA.
Career Highlights
Frost has worked with prestigious institutions such as the University of California and Sansum Medical Research Foundation. His research has paved the way for advancements in cancer treatment methodologies, showcasing his commitment to improving patient outcomes through innovative scientific approaches.
Collaborations
Some of Gregory I Frost's notable coworkers include Robert Stern and Tim M Wong. Their collaborative efforts have contributed to the success of his research and inventions.
Conclusion
Gregory I Frost stands out as a prominent inventor in the field of biochemistry, particularly for his work on human plasma hyaluronidase. His innovative patents and collaborations have the potential to significantly impact cancer treatment and therapeutic practices.