Location History:
- Dedham, MA (US) (2010 - 2015)
- Cambridge, MA (US) (2016 - 2020)
Company Filing History:
Years Active: 2010-2020
Title: Inventor Profile: Grazyna Szymanska
Introduction
Grazyna Szymanska is an accomplished inventor based in Cambridge, MA, known for her significant contributions to the field of immunology. With a total of six patents to her name, she has focused her research on enhancing immune responses, particularly in the context of cancer treatment.
Latest Patents
Grazyna's latest inventions include novel methods for inducing or enhancing an immune response. Her patents involve administering agonistic glucocorticoid-induced TNFR-family-related receptor (GITR) antibodies. This groundbreaking approach provides binding molecules that specifically target GITR, such as human GITR (hGITR), on T cells and dendritic cells. These binding molecules are characterized by their high affinity for hGITR and their ability to function in the presence of a stimulating agent, such as CD3. This agonistic action is vital, as it helps abrogate the suppression of effector (Teff) cells by regulatory (Treg) cells. Grazyna's inventions also cover various aspects including pharmaceutical compositions, nucleic acids, recombinant expression vectors, and host cells for producing these binding molecules. Moreover, her methods allow for detecting human GITR and modulating its activity both in vitro and in vivo.
Career Highlights
Her career has seen her work with notable companies such as Gitr, Inc. and Tolerrx, Inc., where she has furthered her research and development efforts. With a strong emphasis on innovative approaches, Grazyna has made a name for herself in the biotechnology sector.
Collaborations
Throughout her career, Grazyna has collaborated with prominent colleagues, including L Mary Smith and Paul D Ponath. These collaborations have enhanced her research capabilities and have contributed to her success as an inventor.
Conclusion
Grazyna Szymanska’s innovative work in the field of immunology highlights her role as a leading inventor. Her contributions through her patents demonstrate her commitment to developing therapeutic solutions that could potentially transform cancer treatment and enhance immune responses. As she continues her research and innovation, Grazyna remains a vital figure in advancing medical science and improving patient outcomes.