Company Filing History:
Years Active: 1998
Title: Innovations by Grant Mark Holman
Introduction
Grant Mark Holman is an accomplished inventor based in Bryan, TX (US). He has made significant contributions to the field of insect control through his innovative research and development of novel pseudopeptide analogs. With a total of 2 patents, Holman's work focuses on mimicking the biological activity of naturally occurring neuropeptides in insects.
Latest Patents
Holman's latest patents include "Mimetic insect pyrokinin analogs for insect control" and "Mimetic insect kinin analogs for insect control." The first patent discloses novel pseudopeptide analogs of the insect pyrokinin neuropeptide family. These analogs possess biological activity that mimics that of naturally occurring neuropeptides. By adding a hydrophobic moiety to an active portion of the pyrokinin peptides, these analogs exhibit an overall amphiphilic nature. This allows them to penetrate the insect cuticle while retaining biological activity. They can be used for insect control by disrupting the reproductive, developmental, and digestive processes normally regulated by pyrokinins in insects. The second patent reveals novel pseudopeptide analogs of the insect kinin neuropeptide family. These analogs are designed to mimic the biological activity of naturally occurring neuropeptides. By substituting a sterically hindered amino acid compatible with a turn conformation, these analogs exhibit resistance to degradation by angiotensin converting enzyme (ACE) while retaining biological activity. They can disrupt diuretic and myotropic activity in insects, providing a new avenue for insect control.
Career Highlights
Holman works for the United States of America as represented by the Secretary of. His innovative research has positioned him as a key figure in the development of new insect control methods. His patents reflect a deep understanding of neuropeptide biology and its applications in pest management.
Collaborations
Holman has collaborated with notable colleagues such as Ronald J Nachman and Peter E Teal. These partnerships have enhanced the scope and impact of his research in the field of insect control.
Conclusion
Grant Mark Holman is a pioneering inventor whose work in developing mimetic insect neuropeptide analogs has the potential to revolutionize insect control methods. His contributions are significant in advancing the science of pest management and improving agricultural practices.