Graham J Tomblin

Title: Innovations by Graham J Tomblin

Introduction

Graham J Tomblin is a notable inventor based in Tappan, NY (US). He has made significant contributions to the field of DNA purification and concentration. With a total of two patents to his name, his work has implications for various applications in biotechnology and medical research.

Latest Patents

Tomblin's latest patents focus on a process and apparatus for purifying and concentrating DNA from crude mixtures, particularly from human whole blood samples. The technology allows for the collection of DNA that is of usable volume and concentration, ensuring high purity suitable for conventional restriction by various enzymes without the need for further purification. The apparatus consists of an agarose gel disc, typically 5 mm thick and 31 mm in diameter, immersed in an electrophoresis buffer solution. This setup is supported between two 8 micrometer polycarbonate filters within an electric field. The method involves loading a treated sample onto the agarose gel disc and applying an electric field, which impedes the passage of larger DNA molecules while allowing other components to pass through rapidly. The DNA is then eluted and collected in concentrated form.

Career Highlights

Tomblin has been associated with Lifecodes Corporation, where he has contributed to advancements in DNA technology. His work has been instrumental in enhancing the efficiency and effectiveness of DNA purification processes.

Collaborations

Some of his notable coworkers include Karen B Wexler and John P Ford, who have collaborated with him on various projects within the field.

Conclusion

Graham J Tomblin's innovations in DNA purification and concentration represent significant advancements in biotechnology. His patents reflect a commitment to improving methodologies that are crucial for medical and research applications.