This inventor holds 7 USPTO granted patents, plus 1 CIPO patent. Top assignee: Neorx Corporation. Active years: 1990-1997.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile
Company Filing History:
Years Active: 1990-1997
Title: Innovations of Gowsala P Sivam
Introduction
Gowsala P Sivam is a notable inventor based in Edmonds, WA (US). He has made significant contributions to the field of pharmaceuticals, holding a total of 7 patents. His work primarily focuses on the modification of pharmacokinetics of proteins, which has important implications for therapeutic and diagnostic applications.
Latest Patents
One of his latest patents involves the alteration of pharmacokinetics of proteins by charge modification. This patent discloses charge-modified conjugates that comprise a targeting protein bound to a therapeutic or diagnostic agent. By charge-modifying a conjugate to cause an acidic shift in the isoelectric point, it results in a prolonged serum half-life upon in vivo administration, which is beneficial for accumulating a therapeutic agent at the target site. Conversely, charge-modification that causes a basic shift in the isoelectric point reduces serum half-life for diagnostic imaging purposes, leading to higher target-to-background ratios. Another significant patent details targeting substance-diagnostic/therapeutic agent conjugates that are joined by stabilized Schiff base or hydrazone linkages. Additionally, he has described slow release carrier-drug pharmaceuticals that provide advantages related to in vivo administration, including controlled release of the active agent at a target site.
Career Highlights
Gowsala P Sivam is currently associated with Neorx Corporation, where he continues to innovate in the pharmaceutical sector. His work has been instrumental in advancing the understanding and application of drug delivery systems.
Collaborations
He has collaborated with notable colleagues such as Paul G Abrams and A Charles Morgan, Jr., contributing to a dynamic research environment that fosters innovation.
Conclusion
Gowsala P Sivam's contributions to the field of pharmaceuticals through his innovative patents highlight his expertise and commitment to advancing medical science. His work continues to impact therapeutic and diagnostic applications significantly.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile