Gorantla Seeta Ramanjaneyulu

Title: Gorantla Seeta Ramanjaneyulu: Innovator in Pharmaceutical Processes

Introduction

Gorantla Seeta Ramanjaneyulu is a notable inventor based in Secunderabad, India. He has made significant contributions to the field of pharmaceuticals, holding a total of six patents. His work focuses on innovative processes for the preparation of important medicinal compounds.

Latest Patents

One of his latest patents is a process for the preparation of Carvedilol Form II. This cost-effective and industrially feasible process involves the manufacture of crystalline Carvedilol Form-II using novel Carvedilol salts. The method includes reacting 4-(2,3-epoxy propoxy)carbazole with 2-(2-methoxy phenoxy)ethyl amine, followed by acidification with a mineral acid in the presence of an organic solvent. This yields acid addition salts, which are treated with bases in the presence of organic solvents and water, leading to isolation and crystallization from ethyl acetate.

Another significant patent is for the preparation of Olmesartan medoxomil. This process condenses ethyl 4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylate with 4-[2-(trityl tetrazol-5-yl)phenyl]benzyl bromide. The resulting compound undergoes hydrolysis to obtain trityl Olmesartan dihydrate, which is then reacted with 4-chloromethyl-5-methyl-2-oxo-1,3-dioxolene to produce trityl Olmesartan medoxomil. The final step involves deprotecting trityl Olmesartan medoxomil to yield the active pharmaceutical ingredient.

Career Highlights

Gorantla Seeta Ramanjaneyulu has worked with Matrix Laboratories Limited, where he contributed to various innovative projects in the pharmaceutical sector. His expertise in chemical processes has been instrumental in advancing the development of new medications.

Collaborations

He has collaborated with notable coworkers such as Indukuri Venkata Sunil Kumar and Ketavarapu Narasimha Rao. Their combined efforts have led to advancements in pharmaceutical research and development.

Conclusion

Gorantla Seeta Ramanjaneyulu is a distinguished inventor whose work in pharmaceutical processes has led to