The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 01, 2011
Filed:
Jun. 15, 2007
Gorantla Seeta Ramanjaneyulu, Hyderabad, IN;
Bandari Mohan, Hyderabad, IN;
Purna Chandra Ray, Hyderabad, IN;
Madhuresh Kumar Sethi, Hyderabad, IN;
Vijendra Singh Rawat, Hyderabad, IN;
Yerramalla Raja Krishna, Hyderabad, IN;
Vemula Lakshminarayana, Hyderabad, IN;
Mamidi Srinivas, Hyderabad, IN;
Gorantla Seeta Ramanjaneyulu, Hyderabad, IN;
Bandari Mohan, Hyderabad, IN;
Purna Chandra Ray, Hyderabad, IN;
Madhuresh Kumar Sethi, Hyderabad, IN;
Vijendra Singh Rawat, Hyderabad, IN;
Yerramalla Raja Krishna, Hyderabad, IN;
Vemula Lakshminarayana, Hyderabad, IN;
Mamidi Srinivas, Hyderabad, IN;
Matrix Laboratories Ltd., Secunderabad, IN;
Abstract
The present invention provides a process for the preparation of Olmesartan medoxomil by condensing the ethyl 4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylate with 4-[2-(trityl tetrazol-5-yl)phenyl]benzyl bromide to obtain ethyl 4-(1-hydroxy-1-methyl ethyl)-2-propyl-1-{4-[2-(trityl tetrazol-5-yl)phenyl]phenyl}methylimidazole-5-carboxylate and then hydrolyzing ethyl 4-(1-hydroxy-1-methyl ethyl)-2-propyl-1-{4-[2-(trityl tetrazol-5-yl)phenyl]phenyl}methyl imidazole-5-carboxylate to obtain trityl Olmesartan dihydrate followed by reacting trityl Olmesartan dihydrate with 4-chloromethyl-5-methyl-2-oxo-1,3-dioxolene to obtain trityl Olmesartan medoxomil and then deprotecting trityl Olmesartan medoxomil to obtain Olmesartan medoxomil.