Location History:
- Corsico, IT (1980 - 1982)
- Milan, IT (1979 - 2001)
Company Filing History:
2 out of 208 
1 out of 48 
1 out of 117 Years Active: 1979-2001
Title: Giuliano Franchi: Innovator in Antitumoral Glycosides
Introduction
Giuliano Franchi is a notable inventor based in Milan, Italy. He has made significant contributions to the field of pharmaceuticals, particularly in the development of anthracycline glycosides. With a total of 4 patents to his name, Franchi's work has had a profound impact on cancer treatment.
Latest Patents
Franchi's latest patents include innovative compounds such as anthracycline glycosides. One of his key inventions is 4-Demethoxy-4'-deoxydoxorubicin, a new anthracycline glycoside that exhibits outstanding antitumoral activity, even when administered orally. This compound was synthesized through the condensation of 4-demethoxydaunomycinone with 2,3,4,6-tetradeoxy-3-trifluoroacetamido-L-threo-hexopyranosyl chloride. The process involved the elimination of the protecting group via mild alkaline hydrolysis, resulting in 4-demethoxy-4'-deoxydaunorubicin. This intermediate was then brominated to yield the corresponding 14-bromo derivative. A subsequent hydrolysis with sodium formate transformed the brominated intermediate into 4-demethoxy-4'-deoxydoxorubicin, which was eventually isolated as its hydrochloride.
Career Highlights
Throughout his career, Giuliano Franchi has worked with prominent companies in the pharmaceutical industry. Notable among these are Farmitalia Carlo Erba S.p.a. and Società Farmaceutici Italia S.p.a. His work in these organizations has contributed to advancements in drug development and cancer therapies.
Collaborations
Franchi has collaborated with esteemed colleagues such as Sergio Penco and Federico Maria Arcamone. These partnerships have fostered innovation and have been instrumental in the success of his research endeavors.
Conclusion
Giuliano Franchi's contributions to the field of pharmaceuticals, particularly in the development of antitumoral glycosides, highlight his role as a significant inventor. His innovative work continues to influence cancer treatment and showcases the importance of research in advancing medical science.