Giovanni DiPasquale

Title: Giovanni DiPasquale: Inventor in Gene Transfer Research

Introduction

Giovanni DiPasquale is an inventor associated with Kensington, Maryland. His patent work includes a gene-transfer approach using adeno-associated virus (AAV) vectors to deliver exendin-4 to salivary glands. He is associated with the U.S. Department of Health and Human Services, represented by the Secretary. The available information lists 2 patents.

Latest Patents

The listed patent, “AAV Mediated Exendin-4 Gene Transfer to Salivary Glands to Protect Subjects from Diabetes or Obesity,” describes administering an AAV virion carrying a vector that encodes exendin-4 to a subject’s salivary gland. The invention also covers exendin-4 proteins, encoding nucleic acid molecules, and AAV vectors and virions designed to encode the protein. One described embodiment is a fusion protein in which an NGF secretory segment is joined to the amino terminus of an exendin-4 protein domain.

The supplied patent information lists this same invention twice, so it is presented here as one distinct patent title.

Career Highlights

DiPasquale’s listed patent activity focuses on gene transfer and the delivery of therapeutic proteins. The described approach explores salivary glands as a site for AAV-mediated exendin-4 expression, with the stated aim of protecting subjects from diabetes or obesity.

Collaborations

The supplied information names John A. Chiorini and Edoardo Mannucci as DiPasquale’s coworkers. It does not specify their individual roles in the patent or research.

Conclusion

Giovanni DiPasquale’s listed invention centers on AAV-mediated delivery of exendin-4 to salivary glands, reflecting a patent contribution to research into potential approaches for diabetes and obesity.