Company Filing History:
5 out of 3,684 
1 out of 12 Years Active: 2002-2004
Title: Gerhard Höfle: Innovator in Epothilone Derivatives
Introduction
Gerhard Höfle is a notable inventor based in Braunschweig, Germany. He has made significant contributions to the field of chemistry, particularly in the development of epothilone derivatives. With a total of 6 patents to his name, his work has had a considerable impact on pharmaceutical research and development.
Latest Patents
Höfle's latest patents include innovative processes for the preparation of epothilone intermediates. One of his notable inventions involves a method for synthesizing epothilone analogs by enzymatically degrading specific epothilone compounds. This process results in ring-open structures that contain a carboxyl group, which is then esterified. The hydroxyl groups on the moiety are protected, and the resulting compound is oxidized, for example, by ozone, to form a first intermediate. This first intermediate can subsequently react with a triphenylphosphine adduct to yield a compound with an ester group at position 1, which is later hydrolyzed to form a second intermediate.
Career Highlights
Throughout his career, Gerhard Höfle has worked with prominent companies in the pharmaceutical and biotechnology sectors. Notably, he has been associated with Bristol-Myers Squibb Company and Gesellschaft für Biotechnologische Forschung mbH (GBF). His work in these organizations has allowed him to advance his research and contribute to significant innovations in drug development.
Collaborations
Höfle has collaborated with esteemed colleagues in his field, including Gregory D. Vite and Soong-Hoon Kim. These partnerships have fostered a collaborative environment that has led to groundbreaking advancements in the synthesis of epothilone derivatives.
Conclusion
Gerhard Höfle's contributions to the field of chemistry, particularly in the area of epothilone derivatives, highlight his innovative spirit and dedication to advancing pharmaceutical research. His patents and collaborations reflect a commitment to scientific excellence and innovation.