Company Filing History:
Years Active: 2016
Title: Innovations of Georgios Koukos in Thrombotic Disease Research
Introduction
Georgios Koukos is an accomplished inventor based in Boston, MA. He has made significant contributions to the field of thrombotic disease research through his innovative work. His research focuses on the activation of protease-activated receptor-1 (PAR-1) and its implications in various pathological processes.
Latest Patents
Georgios Koukos holds a patent for "PAR-1 activation by metalloproteinase-1 (MMP-1)." This invention addresses the role of matrix metalloproteases (MMPs) in normal and pathological remodeling processes, including atherothrombotic disease, inflammation, angiogenesis, and cancer. The patent details how exposure of platelets to fibrillar collagen activates MMP-1, promoting aggregation through PAR-1. MMP-1 cleaves the PAR-1 extracellular domain at a novel site, activating Rho-GTP signaling pathways, cell shape change, motility, and MAPK signaling. The blockade of MMP-PAR1 has been shown to suppress thrombogenesis under arterial flow conditions and inhibit thrombosis in animal models. This research establishes a link between matrix-dependent activation of metalloproteases and platelet-G protein signaling, identifying MMP-1/PAR-1 as a new target for treating and preventing arterial thrombosis and other thrombotic diseases.
Career Highlights
Georgios Koukos is affiliated with Tufts Medical Center, Inc., where he continues to advance his research. His work has garnered attention for its potential impact on understanding and treating thrombotic diseases. With a focus on innovative solutions, he has contributed to the scientific community's knowledge of platelet activation and its implications for cardiovascular health.
Collaborations
Georgios Koukos collaborates with Athan Kuliopulos, enhancing the research efforts in the field of thrombotic disease. Their partnership has led to significant advancements in understanding the mechanisms of platelet activation and the role of MMP-1 in this process.
Conclusion
Georgios Koukos is a notable inventor whose work in thrombotic disease research has the potential to transform treatment approaches. His patent on PAR-1 activation by MMP-1 highlights the importance of understanding platelet activation in cardiovascular health. Through his career at Tufts Medical Center, Inc., he continues to