George N Mitilenes

Title: Innovations of George N Mitilenes in Liposomal Antineoplastic Agents

Introduction

George N Mitilenes is a notable inventor based in Washington, NJ (US). He has made significant contributions to the field of pharmaceutical formulations, particularly in the development of liposomal antineoplastic agents. With a total of 4 patents to his name, his work has the potential to enhance the efficacy of cancer treatments.

Latest Patents

Mitilenes' latest patents focus on high drug:lipid formulations of liposomal-antineoplastic agents. One of his key inventions provides a method for encapsulating antineoplastic agents in liposomes, achieving a high drug:lipid ratio. This innovative process utilizes an active mechanism to load the drug via a transmembrane ion gradient, preferably a transmembrane pH gradient. The technique boasts trapping efficiencies that approach 100%, allowing for immediate drug loading prior to use, which addresses stability issues related to drug retention in liposomes. The drug:lipid ratios employed are approximately 3-80 fold higher than those found in traditional liposome preparations, while also reducing the release rate of the drug from the liposomes. Additionally, an assay method to determine free antineoplastic agents in a liposome preparation is disclosed.

Career Highlights

George N Mitilenes is associated with The Liposome Company, Inc., where he continues to innovate in the field of drug delivery systems. His work has been instrumental in advancing the understanding and application of liposomal technology in cancer treatment.

Collaborations

Some of his notable coworkers include Lawrence D Mayer and Marcel B Bally, who have collaborated with him on various projects related to liposomal formulations.

Conclusion

George N Mitilenes stands out as a pioneering inventor in the realm of liposomal antineoplastic agents. His innovative approaches and patents contribute significantly to the advancement of cancer therapies.