Location History:
- Newtown, PA (US) (2001)
- Princeton Junction, NJ (US) (1993 - 2004)
Company Filing History:
6 out of 4,770 
1 out of 1,384 
1 out of 832,680 Years Active: 1993-2004
Title: The Innovative Contributions of George E Mark, III
Introduction
George E Mark, III is a notable inventor based in Princeton Junction, NJ (US). He has made significant contributions to the field of biotechnology, holding a total of 8 patents. His work primarily focuses on methods that enhance the efficacy and safety of antibody therapies.
Latest Patents
One of his latest patents is titled "Method for reducing the immunogenicity of antibody variable domains." This unique method identifies and replaces immunoglobulin surface amino acid residues, converting the antigenicity of a first mammalian species to that of a second. The method effectively changes immunogenicity while preserving ligand binding properties. The judicious replacement of exterior amino acid residues does not affect ligand binding but greatly alters immunogenicity. Another significant patent is "Homologous recombination antibody expression system for murine cells." This patent identifies a specific locus in the genome of a murine host cell that facilitates high levels of recombinant gene expression following stable integration via homologous recombination. It discloses the selection of a favorable genomic locus for the insertion and expression of recombinant genes, along with DNA vectors and host cells.
Career Highlights
Throughout his career, George E Mark, III has worked with prominent companies, including Merck & Company, Inc. His experience in the biotechnology sector has allowed him to develop innovative solutions that address critical challenges in antibody therapies.
Collaborations
George has collaborated with notable individuals in his field, including Gregory Franklin Hollis and Bruce L Daugherty. These collaborations have contributed to the advancement of his research and the successful development of his patented technologies.
Conclusion
George E Mark, III is a distinguished inventor whose work has significantly impacted the biotechnology industry. His innovative patents and collaborations reflect his commitment to advancing medical science and improving therapeutic outcomes.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.