Gennadi Nisnevich

Title: Gennadi Nisnevich: Innovator in Pharmaceutical Processes

Introduction

Gennadi Nisnevich is a notable inventor based in Haifa, Israel. He has made significant contributions to the field of pharmaceuticals, particularly in the preparation of dronedarone, a medication used to treat heart conditions. His innovative approach has led to the development of a novel process that enhances the efficiency and stability of pharmaceutical compounds.

Latest Patents

Gennadi Nisnevich holds a patent for a process titled "Process for the preparation of dronedarone." This invention outlines a method that includes the N-acetylation of p-anisidine or p-phenetidine with acetic anhydride. The process further involves reacting the resulting N-(4-alkoxyphenyl)acetamide with 2-bromohexanoyl chloride or bromide in the presence of aluminum chloride or bromide. This innovative method results in the production of N-[3-(2-bromohexanoyl)-4-hydroxyphenyl]acetamide, which is then converted into 2-butyl-5-benzofuranamine hydrochloride and subsequently into dronedarone or its pharmaceutically acceptable salts. The invention also introduces novel intermediates that are stable, solid compounds, obtainable in high yields, and can be easily purified by crystallization.

Career Highlights

Gennadi Nisnevich is associated with Isp Investments Inc., where he continues to work on innovative pharmaceutical processes. His expertise in the field has positioned him as a valuable contributor to advancements in drug development. His work not only focuses on the final product but also emphasizes the importance of stable intermediates in the pharmaceutical manufacturing process.

Collaborations

Gennadi has collaborated with notable professionals in his field, including Arie L Gutman and Lev Yudovitch. These collaborations have further enriched his research and development efforts, leading to more robust and effective pharmaceutical solutions.

Conclusion

Gennadi Nisnevich's contributions to the pharmaceutical industry, particularly through his patent on the preparation of dronedarone, highlight his innovative spirit and dedication to improving drug development processes. His work continues to influence the field and offers promising advancements for future pharmaceutical applications.