Gene M Shearer

Title: Gene M Shearer: Innovator in Immunology

Introduction

Gene M Shearer is a notable inventor based in Bethesda, MD (US). He has made significant contributions to the field of immunology, holding a total of 7 patents. His work primarily focuses on methods to manipulate immune responses, particularly in the context of cancer and autoimmune diseases.

Latest Patents

One of his latest patents is titled "Induction of antigen-specific unresponsiveness by glioblastoma culture supernatants (GCS)." This invention outlines methods for specifically inhibiting an immune response to selected antigens using an immunosuppressive composition derived from a glioblastoma cell line. The method involves obtaining a population of antigen presenting cells (APCs), loading them with specific antigens, and incubating them with the immunosuppressive composition before introducing them into the subject. This approach aims to induce apoptosis and/or anergy in T cells specific to the antigens present on the APCs, thereby selectively inhibiting the immune response without affecting responses to other antigens. Another significant patent addresses the treatment of Kaposi's sarcoma with IL-12, particularly in cases associated with AIDS.

Career Highlights

Gene M Shearer has worked with the United States of America as represented by the Department of Health. His innovative research has led to advancements in therapeutic strategies for complex medical conditions, showcasing his expertise in immunology.

Collaborations

Throughout his career, Gene has collaborated with notable individuals such as Mario S Clerici and Charles S Via. These partnerships have contributed to the development of his groundbreaking patents and research.

Conclusion

Gene M Shearer stands out as a prominent inventor in the field of immunology, with a focus on innovative methods to modulate immune responses. His contributions continue to impact the medical community and advance therapeutic options for patients.