Gary P Schroth

Title: Gary P. Schroth: Innovator in Nucleic Acid Amplification

Introduction

Gary P. Schroth is a prominent inventor based in Foster City, CA (US), known for his significant contributions to the field of nucleic acid amplification. With a total of 13 patents to his name, Schroth has developed innovative methods that enhance the efficiency and specificity of nucleic acid synthesis.

Latest Patents

Among his latest patents is a method for making available a priming oligonucleotide. This invention focuses on novel techniques for synthesizing multiple copies of a target nucleic acid sequence that are autocatalytic. The method allows for automatic cycling without the need to modify reaction conditions such as temperature, pH, or ionic strength. It utilizes a single primer, known as the 'priming oligonucleotide,' which is modified to prevent polymerase extension from its 3'-terminus. This approach amplifies RNA or DNA molecules in vitro while significantly reducing the formation of side-products. The invention provides a high level of specificity and enhances sensitivity in molecular detection techniques.

Another notable patent involves composition kits and methods for performing amplification reactions. Similar to his previous work, this invention emphasizes robust and efficient nucleic acid amplification while minimizing side-products. The method employs a 3' blocked promoter oligonucleotide and optionally includes a means for terminating a primer extension reaction. This innovation also aims to simplify the analysis of amplification reactions, thereby improving the overall sensitivity of detection methods.

Career Highlights

Throughout his career, Gary P. Schroth has worked with several notable companies, including Gen-Probe, Inc. and Genelabs Technologies, Inc. His experience in these organizations has contributed to his expertise in nucleic acid technologies and has facilitated the development of his patented methods.

Collaborations

Schroth has collaborated with several professionals in his field, including Michael McClellan Becker and Steven T. Brentano. These collaborations have likely played a role in advancing his research and innovations.

Conclusion

Gary P. Schroth's contributions to nucleic acid amplification have significantly impacted the field of molecular biology. His innovative methods and patents continue to enhance the specificity and efficiency of nucleic acid synthesis, making him a key figure in this area of research.