Gary Kruppa

Title: Gary Kruppa: Innovator in Protein Analysis

Introduction

Gary Kruppa is a notable inventor based in San Francisco, CA. He has made significant contributions to the field of mass spectrometry, particularly in the analysis of proteins. His innovative approach has paved the way for advancements in understanding protein structures and sequences.

Latest Patents

Gary Kruppa holds a patent for the "Structural determination of intact proteins using mass spectrometry." This invention relates to novel methods for determining the sequence and structure of proteins. It allows for the analysis of intact proteins within a mass spectrometer without the need for preparatory separations. The patent also includes new instrumental developments that enhance the signal from modified proteins and methods for producing controlled protein fragments in the mass spectrometer. This innovative approach eliminates complex microseparations and preparatory chemical steps necessary for cross-linking based protein structure determination. The preferred method involves a top-down analysis of protein structures to search for covalent modifications, where intact proteins are ionized and fragmented within the mass spectrometer.

Career Highlights

Gary Kruppa is associated with Sandia National Laboratories, where he has contributed to various research projects. His work has been instrumental in advancing the field of protein analysis and mass spectrometry.

Collaborations

Gary has collaborated with notable colleagues such as Joseph S Schoeniger and Malin M Young. Their combined expertise has further enhanced the research and development of innovative methods in protein analysis.

Conclusion

Gary Kruppa's contributions to the field of mass spectrometry and protein analysis are noteworthy. His innovative patent has opened new avenues for research and understanding of protein structures. His work continues to influence the scientific community and advance the field.