Location History:
- Encinitas, CA (US) (1989 - 1990)
- San Diego, CA (US) (1986 - 1993)
Company Filing History:
4 out of 8 
4 out of 22 Years Active: 1986-1993
Title: Innovations by Gary F Musso
Introduction
Gary F Musso is a notable inventor based in San Diego, CA, with a significant contribution to the field of biotechnology. He holds a total of 8 patents, showcasing his innovative approach to developing nucleic acid probes and related technologies. His work has implications in various applications, particularly in hybridization assays.
Latest Patents
One of his latest patents involves sulfonamide-derivative compounds for tagging nucleic acid probes. This invention provides nucleic acid hybridization probes that include an N.sup.4 -(substituted amino)cytosine moiety, where the substituted amino group comprises a tag moiety for detection purposes. The methods outlined in this patent detail the preparation of these probes, the intermediates used, and their application in hybridization assays. Typical tag moieties include biotinyl, aminothiadiazole, and fluorescein derivatives, which are connected to modified cytosines through linker moieties. Probes tagged with biotin can be detected by binding to streptavidin or avidin molecules, while those tagged with aminothiadiazole derivatives utilize a carbonic anhydrase molecule for detection. Additionally, probes tagged with fluorescein derivatives can be detected using fluorescence spectroscopic methods without the need for a reporter group.
Career Highlights
Throughout his career, Gary has worked with prominent organizations such as Siska Diagnostics, Inc. and The Salk Institute Biotechnology Industrial Associates, Inc. His experience in these institutions has allowed him to further develop his innovative ideas and contribute to advancements in biotechnology.
Collaborations
Gary has collaborated with notable individuals in his field, including Emil T Kaiser and Soumitra S Ghosh. These collaborations have likely enriched his work and led to further innovations in his research.
Conclusion
Gary F Musso's contributions to biotechnology through his patents and collaborations highlight his role as an influential inventor. His work continues to impact the field, particularly in the development of nucleic acid probes and hybridization assays.