Garabet G Toby

Title: Garabet G Toby: Innovator in Coagulation Factor Research

Introduction

Garabet G Toby is an accomplished inventor based in North Reading, Massachusetts, known for his significant contributions to the field of coagulation factors. With a total of two patents to his name, Toby's work has been crucial in the development of new treatments for coagulation disorders, such as hemophilia A and hemophilia B. His innovative approach combines biochemistry with practical applications, which addresses critical medical needs.

Latest Patents

Toby's most recent inventions include two notable patents that enhance the treatment of factor VIII-related diseases and coagulation disorders.

1. **Factor VIII compositions and methods of making and using same**: This invention relates to compositions that consist of factor VIII coagulation factors linked to an extended recombinant polypeptide (XTEN). It includes isolated nucleic acids encoding these compositions, as well as vectors and host cells that contain them. The methods outlined are intended for the treatment of various diseases, disorders, and conditions associated with factor VIII deficiencies.

2. **Pro-coagulant compounds and methods of use thereof**: This patent presents pro-coagulant compounds, such as pro-coagulant peptides or peptide derivatives, and methods for their utilization and manufacturing. The disclosure includes conjugates formed between a pro-coagulant compound and polypeptides selected from FIX, FVIIa, FVIII, and platelet targeting moieties. These compounds and conjugates are designed to be effective in treating coagulation disorders like hemophilia.

Career Highlights

Toby has worked with prominent companies in the biotechnology sector, including Bioverativ Therapeutics Inc. and Biogen MA Inc. His experience in these organizations has played a significant role in shaping his expertise in developing innovative solutions for serious health issues.

Collaborations

Throughout his career, Garabet G Toby has collaborated with notable professionals in the field, including Volker Schellenberger and Pei-yun Chang. These collaborations have enriched his research and contributed to the effective development of his patented technologies.

Conclusion

Garabet G Toby stands out as an influential inventor whose work in coagulation factors has advanced the treatment options available for patients suffering from coagulation disorders. His commitment to innovation, detailed patent contributions, and collaborations highlight his significant role in the field of biotechnology. Through his ongoing efforts, Toby continues to pave the way for future research and development in the area of coagulation therapies.