Location History:
- Paisley, GB (2001 - 2002)
- Glasgow, GB (2001 - 2004)
Company Filing History:
Years Active: 2001-2004
Title: The Innovations of G. Scott Higgins: Pioneering MALDI Analysis
Introduction
G. Scott Higgins is a remarkable inventor based in Glasgow, GB, who has made significant contributions to the field of spectroscopic analysis. With a total of five patents to his name, Higgins is at the forefront of developing innovative methods that enhance the efficiency and accuracy of mass spectrometry, particularly through Matrix Assisted Laser Desorption/Ionization (MALDI) techniques.
Latest Patents
Higgins' latest patents focus on advanced methodologies and apparatuses for MALDI analysis. He has developed a method that thermalizes large analyte ions in a plume of desorbed material, which significantly improves spectroscopic analysis. The thermalized ions are characterized by having a low or zero mean velocity, allowing them to be presented at a precise moment in time. This innovation reduces artifacts and sharpens spectral peaks, leading to more accurate results.
In one embodiment, the technology employs a matrix or sample holder featuring a cover, baffle, or compartment that contains the desorbed material plume. During the process, the analyte ions undergo collisions to lower their mean velocity and directionality, enabling their passage to a mass analysis instrument in a "thermalized" state.
Another inventive aspect incorporates an optical fiber aligned with a transparent plate, within a vacuum acceleration chamber, to allow for precise specimen selection via a mechanical stage. Adjustments can be made in both the x- and y-directions, thus optimizing the exposure of the specimen to radiation. The inclusion of a thermalizing compartment in a capillary tube has further refined the process, providing a migration path for the thermalized analyte before mass analysis.
Career Highlights
G. Scott Higgins currently works at Sequenom, Inc., a reputable company known for its contributions to genetic analysis and diagnostic technologies. His work at Sequenom, paired with his innovative insights into MALDI analysis, has solidified his standing as a vital contributor to advancements in the scientific community.
Collaborations
Throughout his career, Higgins has collaborated with esteemed colleagues, including David M. Lough and Daniel P. Little. These collaborations have resulted in a synergy of ideas that have propelled the development of sophisticated analytical methods in the realm of mass spectrometry.
Conclusion
In summary, G. Scott Higgins is a distinguished inventor whose innovations in MALDI analysis are shaping the future of spectroscopic analysis. His pioneering methods not only enhance the accuracy of scientific inquiry but also lay the groundwork for future advancements in the field. With five patents under his belt, Higgins demonstrates the power of innovation in transforming complex analytical processes.
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