Fuqiang Hu

Title: Fuqiang Hu: Innovator in Blood-Brain Barrier Research

Introduction

Fuqiang Hu is a prominent inventor based in Hangzhou, China. He has made significant contributions to the field of biomedical research, particularly in the area of blood-brain barrier permeability. With a total of 3 patents to his name, his work focuses on innovative solutions for enhancing drug delivery to the brain.

Latest Patents

One of Fuqiang Hu's latest patents is titled "Use of Axitinib and analogs thereof in preparing blood-brain barrier permeability regulator." This invention relates to the use of Axitinib and its analogs to create a regulator that can reduce blood-brain barrier permeability. The regulator promotes the recovery of blood-brain barrier function from a pathologically impaired state to a more physiological condition. The mechanism involves inhibiting the vascular endothelial cell growth factor-phosphatidylinositol kinase-protein kinase B signaling pathway, which helps maintain the integrity of tight junction proteins like Claudin-5 and Occludin.

Another significant patent is "Blood-brain barrier permeability regulator and use thereof." This invention utilizes SC79 or its analogs to prepare a blood-brain barrier permeability regulator. The active ingredient works by down-regulating the expression of tight junction proteins, thereby increasing blood-brain barrier permeability. This innovation enhances the efficiency of brain-targeting drug delivery systems, particularly those modified with Angiopep-2, improving therapeutic efficacy.

Career Highlights

Fuqiang Hu is affiliated with Zhejiang University, where he conducts his research and development activities. His work has garnered attention for its potential applications in treating diseases that affect blood-brain barrier permeability. His innovative approaches have positioned him as a key figure in the field of neuropharmacology.

Collaborations

Fuqiang Hu collaborates with notable colleagues, including Hong Yuan and Lijuan Wen. Their combined expertise contributes to advancing research in blood-brain barrier permeability and drug delivery systems.

Conclusion

Fuqiang Hu's contributions to the field of blood-brain barrier research are noteworthy. His innovative patents and collaborations reflect his commitment to improving drug delivery methods for neurological conditions. His work continues to pave the way for advancements in biomedical research and therapeutic applications.