Company Filing History:
3 out of 419 
3 out of 227 
Years Active: 2024-2025
Title: Fumiko Chiwaki: Innovator in Cancer Treatment
Introduction
Fumiko Chiwaki is a prominent inventor based in Chuo-ku, Japan. She has made significant contributions to the field of cancer treatment through her innovative research and development of bispecific antibodies. With a total of 3 patents, her work focuses on creating targeted therapies that can improve patient outcomes.
Latest Patents
Chiwaki's latest patents include the development of an anti-TSPAN8/anti-CD3 bispecific antibody and an anti-TSPAN8 antibody. The objective of this invention is to provide effective treatments for human patients suffering from peritoneal disseminated cancer. The antibodies, 16B11 and 16B12, selectively bind to cancer cells and exhibit strong binding activity to TSPAN8. Additionally, the anti-TSPAN8(16B11)-anti-CD3 bispecific antibody has demonstrated cytotoxic activity against TSPAN8-expressing cancer cells in vitro and has shown anti-tumor action in vivo, extending the lifespan of model mice with peritoneal dissemination.
Another significant patent is the anti-CLDN4/anti-CD137 bispecific antibody, which is designed for cancer treatment. This antibody promotes the production of interferon γ by T cells and exhibits cytotoxic activity against cancer cells expressing CLDN4. Importantly, it has been shown to be safely administered to monkeys, indicating its potential for human application.
Career Highlights
Fumiko Chiwaki has worked with notable organizations such as Astellas Pharma GmbH and the National Cancer Center. Her experience in these institutions has allowed her to collaborate with leading experts in the field and contribute to groundbreaking research in cancer therapies.
Collaborations
Chiwaki has collaborated with esteemed colleagues, including Yoshiyuki Tenda and Masatoshi Yuri. These partnerships have further enhanced her research capabilities and have led to significant advancements in the development of bispecific antibodies.
Conclusion
Fumiko Chiwaki's innovative work in the field of cancer treatment through bispecific antibodies showcases her dedication to improving patient care. Her contributions are paving the way for new therapeutic options in oncology.