Fu-Chih Hsu

Title: Fu-Chih Hsu: Innovator in Bacteriophage Detection and Microbe Capture

Introduction

Fu-Chih Hsu is a notable inventor based in Granger, IN (US), recognized for his contributions to the fields of microbiology and biotechnology. He holds 2 patents that focus on innovative methodologies for detecting and manipulating bacteriophages, as well as capturing microbe particles.

Latest Patents

One of Hsu's latest patents is a methodology for the detection, enumeration, propagation, and manipulation of bacteriophages. This method is designed to propagate, enumerate, and quantify bacteriophages in water samples or other aqueous environments. The methodology includes ingredients that stimulate the growth of specific bacterial species susceptible to infection by certain bacteriophages, while inhibiting or rendering inconsequential any interfering background organisms. Key features of the medium involve oxidation-reduction compounds that produce colored or fluorescent products, chromogenic and fluorogenic enzyme substrates, and temperature-independent gelling agents. A preferred combination includes growth medium containing 2,3,5-triphenyl tetrazolium chloride and 5-bromo-4-chloro-3-indolyl-B-D-galactoside, which, when used correctly, results in a dark red bacterial lawn with teal blue-green spots representing individual phage plaques, all visible under standard lighting conditions. This procedure can also be adapted for automatic counting systems under artificial illumination and is applicable to water samples and elution buffers that retain bacteriophages in suspension.

Another significant patent involves methods and apparatus for capturing and releasing microbe particles using amino-functionalized silica substrates. This invention describes an apparatus designed to capture microbe particles, which includes a silica substrate coated with a positively charged material that features an aminopropyl functional group.

Career Highlights

Hsu has worked with esteemed institutions such as the University of Notre Dame Du Lac and Scientific Methods, Inc. His work has significantly advanced the understanding and manipulation of bacteriophages and microbial particles.

Collaborations

Throughout his career, Hsu has collaborated with notable individuals, including David A Battigelli and Hsueh-Chia Chang, contributing to the advancement of his innovative research.

Conclusion

Fu-Chih Hsu's innovative work in bacteriophage detection and microbe capture showcases his significant contributions to microbi