Frederick W Holly

Title: The Innovations of Frederick W. Holly

Introduction

Frederick W. Holly is a notable inventor based in Glenside, PA (US). He has made significant contributions to the field of biochemistry, particularly in the development of somatostatin analogs. With a total of 5 patents to his name, Holly's work has had a profound impact on medical science.

Latest Patents

One of his latest patents involves somatostatin analogs characterized by the structural formula: Cyclo[(X).sub.j -(A).sub.k -(B).sub.1 -Phe-Phe-(D- or L-)Trp-Lys-Thr-Phe-Thr-(C).sub.m]. These analogs are prepared through controlled stepwise procedures starting with individual amino acid components. The peptides developed from this research possess the ability to lower blood glucose levels, inhibit gastric secretion, and suppress the release of growth hormone and glucagon in both humans and animals.

Career Highlights

Holly's career has been marked by his association with Merck & Company, Inc., where he has been able to apply his innovative ideas in a collaborative environment. His work has not only advanced scientific understanding but has also contributed to the development of therapeutic solutions.

Collaborations

Some of his notable coworkers include Daniel F. Veber and Robert G. Strachan. Their collaborative efforts have further enhanced the research and development of new pharmaceutical products.

Conclusion

Frederick W. Holly's contributions to the field of biochemistry through his patents and collaborative work exemplify the spirit of innovation in medical science. His research continues to influence the development of important therapeutic agents.