This inventor holds 1 USPTO granted patent. Top assignee: Dana-Farber-Cancer Institute Inc.. Active years: 2002.
Company Filing History:
Years Active: 2002
Title: Frederick J King: Innovator in Signal Transduction Pathways
Introduction
Frederick J King is a notable inventor based in Brookline, MA (US). He has made significant contributions to the field of molecular biology, particularly in the area of signal transduction pathways. His innovative work has implications for various biological processes and therapeutic applications.
Latest Patents
Frederick J King holds a patent for "Differentiation enhancing factors and uses therefor." This invention relates to novel SH3 domain binding proteins, referred to as DEF polypeptides. The DEF polypeptides comprise several motifs, including a src SH3 consensus binding sequence, four ankyrin repeats, one zinc finger domain, and six copies of a proline-rich tandem repeat. These polypeptides may function as mediators of SH3 domain-dependent signal transduction pathways, influencing cellular gene expression, cytoskeletal architecture, protein trafficking, endocytosis, cell adhesion, migration, proliferation, and differentiation. The patent also describes isolated and antisense nucleic acid molecules, recombinant expression vectors, host cells, and non-human transgenic animals containing an insertion or disruption of the DEF gene. Additionally, diagnostic, screening, and therapeutic methods utilizing the compositions of the invention are provided.
Career Highlights
Frederick J King is associated with the Dana-Farber Cancer Institute Inc., where he continues to advance research in cancer biology and treatment. His work has been instrumental in understanding the mechanisms of cellular signaling and its implications for cancer therapy.
Collaborations
Frederick has collaborated with notable colleagues, including Erding Hu and David F Harris. These collaborations have further enriched his research and contributed to the advancement of knowledge in the field.
Conclusion
Frederick J King is a distinguished inventor whose work on differentiation enhancing factors has the potential to impact various aspects of cellular biology and therapeutic strategies. His contributions to the field are invaluable and continue to inspire further research and innovation.