Fred Rothstein

Title: Fred Rothstein: Innovator in Immune Globulin Purification

Introduction

Fred Rothstein is a notable inventor based in Long Beach, CA (US). He has made significant contributions to the field of biochemistry, particularly in the purification of immune globulins from blood plasma. With a total of 3 patents, Rothstein's work has advanced the efficiency and effectiveness of protein purification methods.

Latest Patents

Rothstein's latest patents include a method for high yield purification of immune globulins from blood plasma and blood plasma intermediates. This innovative method focuses on achieving a high degree of efficiency and a high rate of recovery. The immune globulin source utilized in this process is Cohn's fraction I+II+III or II+III, which is prepared from plasma or plasma intermediates. The purification process involves precipitation of the paste at pH 6.7 to 6.8 in the presence of 20% ethanol and 80% purified water. Following this, a glycine extraction is performed, followed by an anion exchange chromatography column step, resulting in a significantly high yield and high purity of the concentrated protein. Another patent details a similar method, but with a slight variation in pH, set at 5.7 to 5.8.

Career Highlights

Throughout his career, Rothstein has worked with various companies, including Hemacare Corporation and Middlesex Sciences, Inc. His expertise in the field has allowed him to develop methods that are crucial for the production of therapeutic proteins.

Collaborations

Rothstein has collaborated with notable individuals in his field, including Joshua Levy and Bahman Shimiaei. These partnerships have contributed to the advancement of his research and innovations.

Conclusion

Fred Rothstein's contributions to the purification of immune globulins have made a significant impact in the field of biochemistry. His innovative methods continue to enhance the efficiency of protein purification processes.