This inventor holds 3 USPTO granted patents. Top assignees: Betagene, Inc., The University of Texas System, Other. Active years: 2000-2001.
Company Filing History:
2 out of 4 
2 out of 5,630 
1 out of 834,411 Years Active: 2000-2001
Title: Fred Kruse: Innovator in Protein Expression Technologies
Introduction
Fred Kruse is a notable inventor based in Dallas, TX (US), recognized for his contributions to the field of protein expression technologies. With a total of 3 patents, he has made significant advancements in the production of heterologous polypeptides, which have important applications in biotechnology and medicine.
Latest Patents
Fred Kruse's latest patents focus on the recombinant expression of proteins from secretory cell lines. The first patent provides methods for the production of heterologous polypeptides using various recombinantly engineered secretory cell lines. A key feature of these cell lines is the absence of expression of at least one endogenous polypeptide. This allows the host cell machinery, typically used for producing the endogenous polypeptide, to be repurposed for the production of the heterologous polypeptide. The patent also describes methods for engineering cells for high-level expression, large-scale protein production, and treatment of diseases in vivo using viral delivery systems and recombinant cell lines. The second patent similarly addresses the production of heterologous polypeptides, such as amylin, using engineered cell lines. It includes methods for high-level expression, large-scale production, and the isolation of novel amylin receptors.
Career Highlights
Throughout his career, Fred Kruse has worked with prominent organizations, including Betagene, Inc. and the University of Texas System. His work has significantly impacted the field of biotechnology, particularly in the development of innovative methods for protein production.
Collaborations
Fred has collaborated with esteemed colleagues, including Christopher B. Newgard and Karl D. Normington, contributing to advancements in protein expression technologies.
Conclusion
Fred Kruse's innovative work in recombinant protein expression has paved the way for new methodologies in biotechnology. His patents reflect a commitment to enhancing the production of therapeutic proteins, which can lead to significant advancements in medical treatments.