Company Filing History:
Years Active: 1986-1987
Title: Frank V Chisari: Innovator in Hepatitis B Research
Introduction
Frank V Chisari is a prominent inventor based in Del Mar, California. He has made significant contributions to the field of immunology, particularly in the development of vaccines and therapeutic agents for hepatitis B. With a total of 3 patents, his work has had a substantial impact on medical research and treatment options.
Latest Patents
Chisari's latest patents include groundbreaking innovations. One patent focuses on proteinaceous antigens that are conformation-independent. This invention discloses a single polypeptide antigen that includes the amino acid residue sequence and epitope of a conformation-independent antigenic determinant. It also describes methods for its manufacture and use, along with articles of manufacture utilizing the same. Another significant patent involves the use of the pre-S(2) region polypeptide encoded by the hepatitis B virus genome. This polypeptide serves as a T cell proliferating agent and enhances the humoral immune response in animals with a low response to S region-containing immunogens. Additionally, he has developed a synthetic hepatitis B virus vaccine that includes both T cell and B cell determinants. This vaccine comprises chemically synthesized polypeptides that correspond to the amino acid residue sequences of natural, pathogen-related proteins, specifically targeting hepatitis B virus surface antigens.
Career Highlights
Chisari is affiliated with the Scripps Clinic and Research Foundation, where he conducts his research. His work has been instrumental in advancing the understanding of hepatitis B and developing effective vaccines. His innovative approaches have garnered attention in the scientific community, leading to further research and exploration in the field.
Collaborations
Chisari has collaborated with various researchers, including David R Milich, to enhance the scope and impact of his work. These collaborations have facilitated the exchange of ideas and expertise, contributing to the advancement of hepatitis B research.
Conclusion
Frank V Chisari is a notable inventor whose work in hepatitis B research has led to significant advancements in vaccine development and immunology. His contributions continue to influence the field and provide new avenues for treatment and prevention.