Frank R Jirik

Title: Innovations and Contributions of Frank R. Jirik

Introduction

Frank R. Jirik is a notable inventor based in Vancouver, Canada. He has made significant contributions to the field of genetics and molecular biology, holding two patents that showcase his innovative approaches to gene manipulation and therapeutic evaluation.

Latest Patents

One of Jirik's latest patents is titled "Complementation trap." This patent provides methods and DNA constructs for the detection and manipulation of a target eukaryotic gene whose expression is restricted to certain tissues or specialized cell types. The methods include transforming a cell with a first indicator component under the control of a promoter selected for its restricted expression in a particular cell or tissue. The cell is also transformed with a gene trap vector encoding a second indicator component. The cell is allowed to differentiate to produce specialized cell or tissue, which is monitored for expression of both the first and second indicator components. This process allows for the detection of a gene into which the trap vector has integrated, expressed in the same cell or tissue type as the selected promoter.

Another significant patent by Jirik is related to a "Transgenic mouse model for iduronidase deficiency and methods of making." This patent describes a mouse that is homozygous for a disruption in the IDUA gene but has normal expression for the SAT-1 gene. This model can be used for evaluating therapeutic agents for treating mucopolysaccharidosis Type I. By administering therapeutic agents to the mouse, researchers can evaluate tissue pathology associated with iduronidase deficiency. The mouse can also be utilized to assess the ability of a targeting system to deliver therapeutic agents to selected tissues or organs.

Career Highlights

Frank R. Jirik is affiliated with the University of British Columbia, where he continues to advance research in genetics and therapeutic methodologies. His work has been instrumental in developing innovative approaches to gene therapy and understanding genetic disorders.

Collaborations

Jirik has collaborated with notable colleagues, including Lorne A. Clarke and Christopher J. Ong. These collaborations have further enriched his research and contributed to the advancement of genetic studies.

Conclusion

Frank R. Jirik's contributions to the field of genetics through his patents and research at the University of British Columbia highlight his role as an influential inventor. His innovative methodologies continue to pave the way for advancements in gene therapy and the treatment of genetic disorders.