Company Filing History:
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1 out of 48 Years Active: 1977-1998
Title: Frank Kavka: Innovator in Pharmaceutical Chemistry
Introduction
Frank Kavka is a notable inventor based in St. Louis, MO (US). He has made significant contributions to the field of pharmaceutical chemistry, holding a total of 3 patents. His work primarily focuses on the preparation of various compounds that have important applications in medicine.
Latest Patents
Kavka's latest patents include innovative methods for the preparation of nalbuphine with low levels of beta-epimer. He has also developed a process for creating 14-hydroxy-N-ethoxy-carbonyl-norcodeinone. This compound is synthesized by contacting N-ethoxycarbonyl-norcodeinone enol acetate with an aromatic or aliphatic mono-basic or poly-basic peroxy-acid. The reaction conditions are optimized to substitute an -OH group in the 14-position of the norcodeinone enol acetate. In a preferred embodiment, the process involves using a moderately strong acid, an inert organic solvent, and is conducted in the substantial absence of water. Additionally, codeine can be converted to noroxymorphone using this improved method.
Career Highlights
Throughout his career, Frank Kavka has worked with prominent companies such as Mallinckrodt, Inc. and Mallinckrodt Medical, Inc. His expertise in pharmaceutical development has been instrumental in advancing various medical treatments.
Collaborations
Kavka has collaborated with notable colleagues, including Donald E. Robertson and Wilbert Herbert Urry. These partnerships have contributed to the success of his innovative projects.
Conclusion
Frank Kavka's contributions to pharmaceutical chemistry through his patents and collaborations highlight his role as a significant inventor in the field. His work continues to influence the development of important medical compounds.