This inventor holds 2 USPTO granted patents. Top assignees: Ortho Diagnostic Systems Inc., Ortho Pharmaceutical Corporation. Active years: 1996-2001.
Company Filing History:
1 out of 74 
1 out of 377 Years Active: 1996-2001
Title: Frank J McMahon: Innovator in Erythropoietin Research
Introduction
Frank J McMahon is a notable inventor based in Whitehouse Station, NJ (US). He has made significant contributions to the field of biotechnology, particularly in the study of erythropoietin and its receptor binding proteins. With a total of 2 patents, McMahon's work has implications for drug design and therapeutic applications.
Latest Patents
McMahon's latest patents include innovative methods for identifying erythropoietin receptor binding protein. The extracellular domain of the human erythropoietin receptor, known as EPO binding protein (EBP), has been expressed and overproduced. Control of oxygen levels and pH during high-density fermentation allows for the production of the protein variant with the native amino terminus. The methods disclosed permit the efficient recovery of purified EBP, which quantitatively binds EPO. The active purified protein competes with the membrane-associated EPO receptor for binding to EPO and neutralizes EPO-dependent stimulation in a cell-based proliferation assay. Furthermore, the radioligand equilibrium binding constant for this interaction has been determined by immobilizing EBP on agarose gel via a free cysteine. The EBP of the present invention has many uses, including structural determination of the protein by NMR or crystallography, in drug design and discovery, and as a therapeutic. Additionally, a fusion protein of EBP and an immunoglobulin heavy chain was produced, termed EBP-Ig, which serves as a preformed dimerization template useful in drug design and discovery methods. Another patent involves a method of preparing nucleotide probes using a bridging complement, providing labeled nucleotide probes and a procedure for synthesis by coupling two components of the probe.
Career Highlights
Throughout his career, Frank J McMahon has worked with prominent companies such as Ortho Pharmaceutical Corporation and Ortho Diagnostic Systems Inc. His experience in these organizations has contributed to his expertise in the field of biotechnology and patent development.
Collaborations
McMahon has collaborated with notable coworkers, including Linda K Jolliffe and Chander Bahl. These collaborations have likely enhanced his research and innovation efforts.
Conclusion
Frank J McMahon's contributions to the field of biotechnology, particularly in erythropoietin research, demonstrate his innovative spirit and dedication to advancing medical