Frank B Cerra

Title: Innovations by Frank B Cerra in Bioreactor Technology

Introduction

Frank B Cerra is a notable inventor based in Edina, MN (US), recognized for his contributions to bioreactor technology. He holds a total of 3 patents that focus on maintaining animal cells for product production and developing bioartificial liver systems. His work has significant implications for medical treatments, particularly in supporting liver function.

Latest Patents

Cerra's latest patents include innovative methods for maintaining cells for an extended time through entrapment in a contracted gel matrix. This technology is designed to support hepatocyte function and viability, which is crucial for treating patients suffering from hepatic failure. The bioreactor he developed features a feed and waste chamber, along with a cell chamber separated by a selectively permeable membrane. Within the cell chamber, a biocompatible contracted three-dimensional gel matrix entraps animal cells, allowing for efficient nutrient delivery and waste removal.

Another significant patent involves a bioreactor apparatus that utilizes two chambers to create three distinct zones within the system. This design enhances the functionality of the bioartificial liver by allowing for the perfusion of nutrient media and the removal of toxins modified by hepatocytes into a water-soluble form. The bioreactor can be configured as either a hollow fiber or flat-bed system, providing versatility in its application.

Career Highlights

Frank B Cerra is affiliated with the University of Minnesota, where he has made substantial contributions to research in bioreactor technology. His work has been instrumental in advancing the field of regenerative medicine and improving treatment options for liver diseases.

Collaborations

Cerra has collaborated with esteemed colleagues such as Wei-Shou Hu and Scott Lyle Nyberg, further enhancing the impact of his research through teamwork and shared expertise.

Conclusion

Frank B Cerra's innovative work in bioreactor technology and his patents play a crucial role in the development of medical treatments for liver function support. His contributions continue to influence the field of regenerative medicine and offer hope for patients with hepatic failure.