Francoise Pflumio

Title: Francoise Pflumio: Innovator in Lentiviral Research

Introduction

Francoise Pflumio is a notable inventor based in Vitry/Siene, France. He has made significant contributions to the field of molecular biology, particularly in the development of lentiviral vectors. With a total of 5 patents, his work has advanced our understanding of gene transfer mechanisms.

Latest Patents

One of Pflumio's latest patents focuses on "Lentiviral triplex DNA, and vectors and recombinant cells containing lentiviral triplex DNA." This invention provides nucleic acids, vectors, viruses, and recombinant cells that comprise triple-stranded structures. These structures result from the central initiation and termination of HIV-1 reverse transcription at the center of HIV-1 linear DNA genomes. The triplex structures can act as a cis-determinant of HIV-1 DNA nuclear import, allowing for the infection of non-dividing target cells. Notably, the presence of the DNA triplex sequence in an HIV vector significantly stimulates gene transfer in hematopoietic stem cells. The invention also outlines methods for using these triplex structures to create recombinant cells, as well as methods for utilizing these cells to express proteins of interest both in vitro and in vivo.

Career Highlights

Francoise Pflumio has worked with prestigious institutions such as Institut Pasteur and the National Institute of Health and Medical Research (INSERM). His research has been pivotal in the field of gene therapy and lentiviral vector development.

Collaborations

Pflumio has collaborated with notable colleagues, including Pierre Charneau and Veronique Zennou, who have contributed to his research endeavors.

Conclusion

Francoise Pflumio's innovative work in lentiviral research has made a significant impact on the field of molecular biology. His patents and collaborations continue to influence advancements in gene therapy and related areas.