This inventor holds 1 USPTO granted patent. Top assignee: Leland Stanford Junior University. Active years: 2017.
Company Filing History:
Years Active: 2017
Title: Innovations of Francois St-Pierre in Neuronal Imaging
Introduction
Francois St-Pierre is a notable inventor based in Stanford, California. He has made significant contributions to the field of neuroscience through his innovative work on fluorescent protein voltage sensors. His inventions are aimed at enhancing the understanding of neuronal electrical activity.
Latest Patents
Francois St-Pierre holds a patent for "Fluorescent protein voltage sensors for measuring membrane potential and imaging high-frequency neuronal electrical activity." This invention relates to engineered protein voltage sensors that consist of a voltage-sensing domain with four transmembrane domains linked to a circularly permuted fluorescent protein. This configuration is inserted into the extracellular loop between the third and fourth transmembrane segments of the voltage-sensing domain. These fluorescent protein voltage sensors are capable of measuring the electrical activity of neurons, including single action potentials, trains of action potentials, and subthreshold potential changes. They are particularly useful for imaging high-frequency neuronal electrical activity. Additionally, these sensors can be applied to measure the membrane potential of various cell types, including cardiac and endocrine cells, and for screening agents that target ion channels.
Career Highlights
Francois St-Pierre is affiliated with Leland Stanford Junior University, where he continues to advance his research in the field of neuronal imaging. His work has garnered attention for its potential applications in understanding complex neuronal behaviors and for developing new methodologies in cellular imaging.
Collaborations
Francois has collaborated with Michael Z Lin, further enhancing the impact of his research in the scientific community.
Conclusion
Francois St-Pierre's innovative contributions to the field of neuroscience through his patented fluorescent protein voltage sensors represent a significant advancement in the ability to measure and visualize neuronal electrical activity. His work continues to influence research and applications in neuroscience.