Franck Duclos

Title: Franck Duclos: Innovator in Gene Replacement Therapy

Introduction

Franck Duclos is a prominent inventor based in Iowa City, IA (US). He has made significant contributions to the field of gene replacement therapy, particularly in the treatment of muscular dystrophy. With a total of 4 patents to his name, Duclos is recognized for his innovative approaches to addressing genetic disorders.

Latest Patents

One of his latest patents focuses on gene replacement therapy for muscular dystrophy. This invention discloses a method for treating patients suffering from sarcoglycan-deficient limb-girdle muscular dystrophy. The therapy aims to produce extensive long-term expression of the sarcoglycan species, restoring the entire sarcoglycan complex. This results in the stable association of alpha-dystroglycan with the sarcolemma and eliminates the morphological markers of the disease. Another aspect of this invention involves determining specific defective sarcoglycan species in patient tissue through cultured muscle cells. Additionally, Duclos has developed methods for screening therapeutic agents useful in treating this condition.

Another significant patent involves the identification of a nucleic acid sequence encoding the mammalian 35 kDa non-dystrophin component, known as delta-sarcoglycan. This invention includes the amino acid sequence and an immunogenic peptide of delta-sarcoglycan. The peptide can stimulate the production of antibodies that specifically bind to delta-sarcoglycan. Furthermore, methods to identify mutations in the delta-sarcoglycan gene associated with autosomal recessive limb-girdle muscular dystrophy are disclosed, enabling the design of nucleic acid probes for diagnosis.

Career Highlights

Throughout his career, Franck Duclos has worked with the University of Iowa Research Foundation, contributing to various research initiatives. His work has focused on advancing the understanding and treatment of muscular dystrophy through innovative gene therapies.

Collaborations

Duclos has collaborated with notable individuals in the field, including Kevin P Campbell and Volker Straub. These partnerships have furthered his research and development efforts in gene therapy.

Conclusion

Franck Duclos is a key figure in the field of gene replacement therapy, with a focus on muscular dystrophy. His innovative patents and collaborations highlight his commitment to advancing medical science and improving patient outcomes.