Location History:
- Basle, CH (1988)
- Basel, CH (1991 - 1996)
Company Filing History:
Years Active: 1988-1996
Title: Insights into the Innovations of Francis Muller
Introduction
Francis Muller is a prominent inventor based in Basel, Switzerland, known for his significant contributions to the fields of molecular biology and biotechnology. With four patents to his name, Muller has established himself as a key player in developing innovative detection methods and energy transfer systems.
Latest Patents
Muller's latest patents include groundbreaking work in the detection of nucleic acids using a hairpin-forming oligonucleotide. This innovative process allows for the detection of a nucleic acid sequence in a homogeneous assay format, utilizing an energy transfer system. The process features a 5' labeled primer that includes a self-complementary sequence, enabling an amplification or extension procedure followed by detection with a 3' labeled probe. This novel approach ensures that the labels are spatially close following hybridization, making the detection more efficient. Additionally, he has developed energy-transfer systems involving derivatives of lumazine and ruthenium, which are used for measuring distances within or between different molecules, especially in the context of DNA or RNA sequences.
Career Highlights
Currently, Francis Muller works at Hoffmann-La Roche Inc., a leading global healthcare company that emphasizes innovation in pharmaceuticals and diagnostics. His work has played a significant role in advancing the understanding and application of molecular detection methods, paving the way for new research and commercial applications.
Collaborations
Throughout his career, Muller has collaborated with esteemed colleagues such as Wilhelm Bannwarth and Dieter Schmidt. These collaborations have led to further advancements in the technologies associated with his patents and have fostered a vibrant research environment that encourages innovation.
Conclusion
Francis Muller continues to be an influential figure in the realm of molecular detection and energy transfer systems. His innovative patents reflect his dedication to advancing scientific knowledge and practical applications within the biotechnological landscape. Through his work, Muller not only contributes to his company but also to the broader scientific community, ensuring that his inventions have a lasting impact.