Francis Keppler

Title: The Innovative Contributions of Francis Keppler

Introduction

Francis Keppler is a notable inventor based in Philadelphia, PA. He has made significant contributions to the field of biochemistry, particularly in understanding the metabolic pathways involving 3-deoxyglucosone. His work has implications for therapeutic methods aimed at alleviating the harmful effects associated with this compound.

Latest Patents

Keppler holds a patent titled "Methods for alleviating deleterious effects of 3-deoxyglucosone." This patent discloses a class of compounds that inhibit the enzymatic conversion of fructose-lysine into fructose-lysine-3-phosphate in an ATP-dependent reaction. The normal functioning of this metabolic pathway involves the breakdown of fructose-lysine-3-phosphate to form free lysine, inorganic phosphate, and 3-deoxyglucosone. The latter is known to be a reactive protein-modifying agent. His research highlights the potential for detoxifying 3-deoxyglucosone by reducing it to 3-deoxyfructose or preventing its reaction with endogenous proteins, which leads to the formation of advanced glycation end-product modified proteins.

Career Highlights

Keppler is affiliated with the Fox Chase Cancer Center, where he conducts his research. His work is pivotal in exploring new therapeutic avenues for conditions related to advanced glycation end-products. His innovative approach has garnered attention in the scientific community.

Collaborations

Keppler collaborates with Truman R. Brown, enhancing the research efforts at the Fox Chase Cancer Center. Their combined expertise contributes to the advancement of knowledge in their field.

Conclusion

Francis Keppler's contributions to the understanding of 3-deoxyglucosone and its metabolic pathways are invaluable. His patent and ongoing research hold promise for developing therapeutic methods to mitigate the adverse effects of this compound.