Francesco Ricci

Title: Francesco Ricci: Innovator in Electrochemical Sensing Technologies

Introduction

Francesco Ricci is a prominent inventor based in Rome, Italy, known for his significant contributions to the field of electrochemical sensors. With a total of three patents to his name, Ricci has developed innovative methods that enhance the functionality and accuracy of these sensors in complex environments.

Latest Patents

One of Ricci's latest patents is titled "Dual-reporter electrochemical sensors with drift correction." This invention encompasses novel methods of operating electrochemical sensors, particularly aptamer-based sensors, to analyze complex samples such as flowing whole blood, both in vitro and in vivo. In challenging environments, electrochemical sensors often experience drift, complicating the interpretation of sensor output regarding target concentration. Ricci's method utilizes a dual-reporter recognition element that generates a first sensing current responsive to target binding and environmental factors, alongside a second reference current affected solely by environmental factors. This reference current provides crucial information about environmentally-induced drift, allowing for the subtraction of drift effects. By eliminating drift artifacts, these electrochemical sensors can be effectively deployed to analyze complex samples like whole blood in vivo.

Another notable patent by Ricci is "Nucleotide-based probes and methods for the detection and quantification of macromolecules and other analytes." This invention provides unimolecular oligonucleotide probes designed for detecting a target in a sample. The probes utilize target binding-induced structural changes to identify the presence of the target within the sample. Additionally, the patent outlines methods for employing these probes to detect targets effectively.

Career Highlights

Francesco Ricci has had a distinguished career, working with esteemed institutions such as the University of California and A. Menarini Industrie Farmaceutiche Riunite S.r.l. His work has significantly advanced the field of electrochemical sensing, making him a notable figure in the scientific community.

Collaborations

Throughout his career, Ricci has collaborated with prominent researchers, including Kevin Plaxco and Giuseppe Palleschi. These collaborations have further enriched his research and contributed to the development of innovative sensing technologies.

Conclusion

Francesco Ricci's contributions to electrochemical sensing technologies have made a lasting impact on the field. His innovative patents and collaborations highlight his dedication to advancing scientific knowledge and practical applications in complex sample analysis.