Florian Then

Title: Florian Then: Innovator in Antibody Development

Introduction

Florian Then is a notable inventor based in Boston, MA (US). He has made significant contributions to the field of biotechnology, particularly in the development of antibodies that target specific proteins associated with neurodegenerative diseases.

Latest Patents

Florian Then holds a patent for "Anti-acetylated huntingtin antibodies and uses thereof." This invention includes methods for preparing acetylated Huntingtin (Htt) polypeptides, acetylated Htt polypeptide antigens, and antibodies that specifically recognize acetylated epitopes on Htt polypeptides. The patent also details the preparation and use of antibodies that bind to acetylated residues on Htt polypeptides, particularly focusing on the lysine corresponding to the K444 residue of the full-length, wild-type Htt polypeptide. Additionally, the invention encompasses hybridoma cell lines that produce antibodies specifically binding to acetylated Htt polypeptides.

Career Highlights

Florian Then is associated with The General Hospital Corporation, where he continues to advance his research and development efforts. His work is pivotal in understanding and potentially treating conditions related to Huntington's disease.

Collaborations

Florian collaborates with esteemed colleagues such as Dimitri Krainc and Hyunkyung Jeong, contributing to a robust research environment focused on innovative solutions in biotechnology.

Conclusion

Florian Then's contributions to the field of antibody development highlight his role as an influential inventor. His work not only advances scientific understanding but also holds promise for future therapeutic applications.