Florence Mahlberg

Title: Florence Mahlberg: Innovator in Protein Production

Introduction

Florence Mahlberg is a notable inventor based in Suresnes, France. She has made significant contributions to the field of biotechnology, particularly in the production of human proteins. Her innovative work has led to advancements in the efficient production of apolipoprotein A1, a crucial protein in human health.

Latest Patents

Florence Mahlberg holds a patent for the "High yield production of human apolipoprotein A1 in E. coli." This patent describes a method for preparing apolipoprotein A1 using a T7 RNA polymerase/promoter bacterial expression system. The process optimizes yield and facilitates the purification of the protein. The apolipoprotein A1 cDNA is cloned into an Escherichia coli plasmid containing a bacteriophage T7 RNA polymerase promoter. The recombinant plasmid is then transferred to an E. coli strain that has inducible bacteriophage T7 RNA polymerase. This innovative method allows for the isolation of apolipoprotein A1 from the culture, with preferred embodiments including a purification tag that enhances the process.

Career Highlights

Florence Mahlberg is associated with the American Cyanamid Company, where she has applied her expertise in biotechnology. Her work has contributed to the understanding and production of essential human proteins, showcasing her commitment to advancing scientific knowledge and practical applications in the field.

Collaborations

Florence has collaborated with notable colleagues such as Sohail Malik and Sotirios K Karathanasis. These partnerships have further enriched her research and development efforts, leading to innovative solutions in protein production.

Conclusion

Florence Mahlberg's contributions to the field of biotechnology, particularly in the production of human apolipoprotein A1, highlight her role as a pioneering inventor. Her work not only advances scientific understanding but also has practical implications for health and medicine.