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Title: Innovations in Cancer Immunotherapy by Florence A. Depontieu
Introduction
Florence A. Depontieu is a notable inventor recognized for her contributions to cancer immunotherapy. Based in Lyons, France, she has made significant strides in the field of melanoma research. Her innovative work focuses on the development of phosphopeptides as potential vaccines against melanoma, a serious form of skin cancer.
Latest Patents
Florence A. Depontieu holds a patent for "Phosphopeptides as melanoma vaccines." This patent details the characterization of a total of 175 HLA-DR-associated phosphopeptides. These were identified using sequential affinity isolation, biochemical enrichment, mass spectrometric sequencing, and comparative analysis. Many of these phosphopeptides are derived from source proteins that may play roles in cancer development, growth, and metastasis. Notably, most of these peptides are expressed exclusively by either melanomas or transformed B cells, indicating the potential to define cell type-specific phosphatome 'fingerprints.' Furthermore, she generated HLA-DRβ1*0101-restricted CD4T cells specific for a phospho-MART-1 peptide identified in two melanoma cell lines. These T cells demonstrated specificity for phosphopeptide-pulsed antigen-presenting cells as well as for intact melanoma cells. The MHC II-restricted phosphopeptides recognizable by human CD4T cells represent promising targets for cancer immunotherapy.
Career Highlights
Throughout her career, Florence A. Depontieu has worked with prestigious institutions, including The Johns Hopkins University and the University of Virginia. Her research has significantly advanced the understanding of melanoma and the development of targeted immunotherapies.
Collaborations
Florence has collaborated with esteemed colleagues such as Suzanne L. Topalian and Donald F. Hunt. These collaborations have further enriched her research and contributed to the advancement of cancer treatment methodologies.
Conclusion
Florence A. Depontieu's innovative work in the field of cancer immunotherapy, particularly through her patent on phosphopeptides, showcases her dedication to advancing medical science. Her contributions are vital in the ongoing fight against melanoma and highlight the importance of targeted therapies in cancer treatment.