Company Filing History:
Years Active: 2001
Title: Ferhat Ilhan: Innovator in Beta-Lactam Antibiotics
Introduction
Ferhat Ilhan is a notable inventor based in Munich, Germany. He has made significant contributions to the field of antibiotic synthesis, particularly through his innovative patent related to beta-lactam antibiotics. His work has implications for the pharmaceutical industry and antibiotic production.
Latest Patents
Ferhat Ilhan holds a patent for the "Synthesis of beta-lactam antibiotics with immobilized penicillin amidase." This patent describes a method for synthesizing beta-lactam antibiotics by reacting an amino-beta-lactam component with a corresponding amino-group-containing acylating side-chain component. The process utilizes penicillin amidase that is covalently immobilized on support particles. The resulting beta-lactam antibiotic product is solubilized by adding an acid, such as sulfuric acid, to lower the pH to 1.0 at a temperature range of 0°C to +5°C. The immobilized penicillin amidase is substantially inactivated by the acid, but can be reactivated for reuse in antibiotic synthesis by treatment with a buffer having a neutral pH. The antibiotics produced through this method include ampicillin, amoxicillin, cephalexin, cefaclor, and cefadroxil. Various support particles can be used, including those with a macroporous structure and a particle diameter of 10-1000 µm, particles with oxirane groups, synthetic polymer particles, and inorganic particles like porous glass.
Career Highlights
Ferhat Ilhan is associated with Unifar Kimya Sanayi ve Ticaret A.Ş., where he continues to contribute to advancements in antibiotic synthesis. His innovative approach to utilizing immobilized enzymes has positioned him as a key figure in the field.
Collaborations
Ferhat Ilhan collaborates with Dieter Kraemer, enhancing the research and development efforts in antibiotic production.
Conclusion
Ferhat Ilhan's work in the synthesis of beta-lactam antibiotics showcases his innovative spirit and dedication to improving pharmaceutical processes. His contributions are vital for the ongoing development of effective antibiotics.