Fangze Chi

Title: Fangze Chi: Innovator in Pharmaceutical Chemistry

Introduction

Fangze Chi is a notable inventor based in Beijing, China. He has made significant contributions to the field of pharmaceutical chemistry, particularly in the resolution of chiral compounds. His innovative methods have the potential to enhance the efficacy of pharmaceutical products.

Latest Patents

Fangze Chi holds a patent for a resolution method for axial chiral enantiomers of lesinurad. This method utilizes inexpensive and readily available quinoline natural products and their derivatives as resolving agents. The process involves reacting these agents with lesinurad racemate in an organic solvent to form a salt. The salt is then dissociated through acidification to yield optically pure (R)- or (S)-2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio)acetic acid. The method achieves a chiral purity of up to 100% for the R configuration and a total yield of 90% or more. The S configuration can reach a chiral purity of up to 99.9% with a total yield of 80% or more.

Career Highlights

Fangze Chi is currently associated with China Resources Saike Pharmaceutical Co., Ltd. His work focuses on developing innovative methods for pharmaceutical applications, contributing to advancements in drug formulation and efficacy.

Collaborations

Fangze Chi collaborates with esteemed colleagues, including Deqian Bian and Moyi Liu. Their combined expertise fosters a productive research environment that drives innovation in pharmaceutical chemistry.

Conclusion

Fangze Chi's contributions to the field of pharmaceutical chemistry, particularly through his patented resolution method for chiral enantiomers, highlight his role as an innovator. His work not only advances scientific knowledge but also has practical implications for the pharmaceutical industry.