Title: Fangyong Du: Innovator in Protein Engineering
Introduction
Fangyong Du is an accomplished inventor based in New Haven, CT (US). He is currently associated with Adagene Inc., where he focuses on advancements in protein engineering. Despite having no granted patents to his name, his contributions to the field are noteworthy.
Latest Patent Applications
Fangyong Du has been involved in several significant patent applications. One of his latest applications is titled "Heterodimeric Proteins with Fc Mutations." This application provides heterodimeric proteins comprising polypeptides with engineered residues that form disulfide bonds and/or salt bridges. It also includes activatable antibodies targeting CD3 and/or HER2, along with compositions, methods of manufacture, and methods of treatment using these proteins and antibodies.
Another notable application is "An Integrated System for Library Construction, Affinity Binder Screening and Expression Thereof." This application describes a recombinant polynucleotide suitable for use in a display vector. The polynucleotide includes a first nucleic acid sequence encoding an amino acid sequence to be displayed on a surface, along with pre-selected restriction sites and a second nucleic acid sequence encoding a surface peptide capable of being displayed. Corresponding display vectors that can be converted into expression vectors in a high-throughput fashion are also provided.
Conclusion
Fangyong Du's work at Adagene Inc. highlights his innovative approach to protein engineering, particularly through his latest patent applications. His contributions are paving the way for advancements in the field, showcasing the potential of engineered proteins in therapeutic applications.