Company Filing History:
Years Active: 2010-2013
Title: Innovations of Evangelos Moudrianakis in Anti-HIV and Anti-Cancer Research
Introduction
Evangelos Moudrianakis is a notable inventor based in Baltimore, MD (US). He has made significant contributions to the field of medicinal chemistry, particularly in the development of new compounds with potential therapeutic applications against HIV and cancer. With a total of two patents to his name, Moudrianakis continues to push the boundaries of scientific research.
Latest Patents
His latest patents focus on the synthesis of heterocyclic and carbonate derivatives of nordihydroguaiaretic acid (NDGA). The innovative reactions involve the use of various alkyl chlorides, 1-piperidinecarbonyl chloride, methyl chloroformate, or 1,1'-carbonyldiimidazole under alkaline conditions. These reactions yield corresponding phenol ethers, carbamates, and carbonates with impressive yields ranging from 67% to 83%. Among these derivatives, nitrogen-containing compounds were converted to hydrochloride salts, demonstrating good solubility and stability in aqueous solutions. Notably, these new compounds exhibit potent activities against HIV Tat-regulated transactivation in cos-7 cells. The most active transcription inhibitor from this series, compound 5b, has an IC of 0.88 µM.
Career Highlights
Evangelos Moudrianakis is affiliated with The Johns Hopkins University, where he conducts his research. His work is characterized by a strong focus on developing novel therapeutic agents that can combat serious health issues such as HIV and cancer. His innovative approach to drug design has garnered attention in the scientific community.
Collaborations
Moudrianakis collaborates with esteemed colleagues, including Ru Chih C Huang and Apostolos Gittis. These partnerships enhance the research efforts and contribute to the advancement of their shared goals in medicinal chemistry.
Conclusion
Evangelos Moudrianakis is a prominent inventor whose work in developing anti-HIV and anti-cancer agents showcases his commitment to improving health outcomes through innovative research. His contributions to the field are significant and continue to inspire future advancements in medicinal chemistry.