Eugenio Tisselli

Title: Eugenio Tisselli: Innovator in Pharmaceutical Chemistry

Introduction

Eugenio Tisselli is a notable inventor based in Mexico City, MX. He has made significant contributions to the field of pharmaceutical chemistry, particularly in the synthesis of important compounds. His innovative methods have the potential to enhance the production of vital medications.

Latest Patents

Eugenio Tisselli holds a patent for a method of alkylating the alpha carbon of the 2-methylbutyrate secondary chain of lovastatin. This method allows for the production of simvastatin from lovastatin in high yield and pharmaceutical purity. The process involves forming an amide of lovastatin and protecting the free hydroxyl groups with hexamethyldisilazane (HMDS). This technique simplifies the methylation of the protected lovastatin amide and facilitates the removal of protecting groups through water quenching. The resulting simvastatin amide can be hydrolyzed to form simvastatin acid, which is then converted into a simvastatin ammonium salt, lactonized, and recrystallized to achieve high purity.

Career Highlights

Eugenio Tisselli is associated with Fermic S.A. de C.V., where he applies his expertise in pharmaceutical chemistry. His work has contributed to advancements in the synthesis of important pharmaceutical compounds, showcasing his innovative approach to chemical processes.

Collaborations

Eugenio has collaborated with notable colleagues, including Edvige Galeazzi and Orestes Martinez. These partnerships have fostered a collaborative environment that enhances research and development in their field.

Conclusion

Eugenio Tisselli's contributions to pharmaceutical chemistry through his innovative patent demonstrate his commitment to advancing medical science. His work not only improves the synthesis of essential medications but also highlights the importance of innovation in the pharmaceutical industry.