Location History:
- Proteos, SG (2020)
- Singapore, SG (2021)
Company Filing History:
3 out of 1,476 
2 out of 223 
1 out of 238 
Years Active: 2020-2024
Title: The Innovative Contributions of Ernesto Guccione
Introduction
Ernesto Guccione is a prominent inventor based in Singapore, known for his significant contributions to cancer research through innovative patent applications. With a total of three patents, Guccione has focused on developing methods for treating various types of cancer, particularly those characterized by high levels of MDM4 protein.
Latest Patents
One of Guccione's latest patents involves the direct and selective inhibition of MDM4 for the treatment of cancer. This application addresses cancers such as melanoma, breast, colon, lung cancers, glioblastoma, and retinoblastoma. The invention demonstrates that inhibiting MDM4, for instance, through antisense RNA, can lead to the growth inhibition of cancer cells and enhance sensitivity to chemotherapy or targeted therapies. Additionally, the patent provides methods for identifying patients who would benefit most from this treatment by comparing specific transcript levels. Another notable patent focuses on a method of treating cancer using antisense oligonucleotides that target PRDM15. This invention allows for the modulation of PRDM15 activity, which is crucial in cancer treatment. It also includes a method for determining prognosis or selecting therapeutic strategies for cancer patients by assessing PRDM15 nucleic acid, protein, or activity levels in samples.
Career Highlights
Guccione has worked with esteemed organizations such as the Agency for Science, Technology and Research and Vib Vzw. His work in these institutions has allowed him to advance his research and contribute to the field of cancer treatment significantly.
Collaborations
Throughout his career, Guccione has collaborated with notable professionals, including Jean-Christophe Marine and Marco Bezzi. These collaborations have further enriched his research and innovation in cancer therapies.
Conclusion
Ernesto Guccione's innovative work in cancer research and treatment exemplifies the impact of dedicated inventors in the medical field. His patents reflect a commitment to improving patient outcomes through targeted therapies.