The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 05, 2021
Filed:
Sep. 04, 2017
Applicant:
Agency for Science, Technology and Research, Singapore, SG;
Inventors:
Ernesto Guccione, Singapore, SG;
Keng Boon Dave Wee, Singapore, SG;
Assignee:
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH, Singapore, SG;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/11 (2006.01); C12N 15/113 (2010.01); A61P 35/00 (2006.01); A61K 9/127 (2006.01);
U.S. Cl.
CPC ...
C12N 15/113 (2013.01); A61K 9/127 (2013.01); A61P 35/00 (2018.01);
Abstract
The present invention relates to antisense oligonucleotides for modulating the activity of PRDM15 and use thereof in the treatment of cancer. In particular, said antisense oligonucleotides are capable of inducing the skipping of an exon of a PRDM15 mRNA. The present invention also relates to a method for determining prognosis in a patient with cancer, or selecting a therapeutic strategy for a patient with cancer, by assessing the level of PRDM15 nucleic acid, protein or activity in a sample.