Company Filing History:
4 out of 4,943 
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1 out of 1 Years Active: 1990-2012
Title: The Innovative Contributions of Ernest A. Knesel
Introduction
Ernest A. Knesel is a notable inventor based in Greensboro, NC (US), recognized for his significant contributions to the field of cytology. With a total of 7 patents to his name, Knesel has developed innovative methods and apparatuses that enhance the efficiency and accuracy of cell sample preparation and analysis.
Latest Patents
One of Knesel's latest patents is a cell sample preparation method and apparatus. This invention provides an automatic thin-layer cell sample slide preparation process that eliminates the need for human intervention. The apparatus measures a cell sample to derive a measurement, which is then used to estimate the total cellularity of the sample. Based on this estimation, a differential volume of diluent is dispensed to create a cell suspension. In another embodiment, a differential volume of the cell suspension and a differential volume of cell adherent are combined to form a cell mixture, which is then dispensed onto a sample slide.
Another significant patent is an interactive automated cytology method that incorporates both manual and automated processes. This system expedites the handling of samples, reducing the likelihood of false negatives while maintaining a low rate of false positives. The computerized system identifies and displays the most relevant cells for the cytologist, who then reviews these cells before inputting their analysis into the automated system. This collaborative approach enhances the accuracy of the cytological evaluation.
Career Highlights
Throughout his career, Knesel has worked with prominent companies such as Hoffmann-La Roche Inc. and Autocyte, Inc. His experience in these organizations has contributed to his expertise in developing innovative solutions in cytology.
Collaborations
Knesel has collaborated with notable professionals in his field, including Charles L. Carrico, Jr. and William Alan Fox. These collaborations have further enriched his work and contributed to advancements in cytological methods.
Conclusion
Ernest A. Knesel's innovative patents and contributions to cytology demonstrate his commitment to improving medical diagnostics. His work continues to influence the field, making significant strides in the preparation and analysis of cell samples.
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